While GLP-1 medications are highly effective for weight loss, some patients experience side effects, especially during the first few weeks. The good news? Most side effects are temporary and manageable with the right strategies.

Most Common Side Effects

1. Nausea (Most Common)

About 20-40% of patients experience nausea, particularly in the first 4-8 weeks.

Management Strategies:

• Eat smaller, more frequent meals (5-6 mini meals vs 3 large ones)
• Avoid high-fat and greasy foods
• Try ginger tea or ginger candies
• Don't lie down immediately after eating
• Eat slowly and chew thoroughly
• Stay hydrated with small sips throughout the day

2. Decreased Appetite

While this is the desired effect, some patients find it challenging to eat enough.

Management Strategies:

• Focus on nutrient-dense foods
• Don't skip meals - eat even if not hungry
• Use protein shakes to meet nutritional needs
• Set meal reminders on your phone
• Work with a dietitian to ensure adequate nutrition

3. Digestive Issues

Constipation, diarrhea, or general digestive upset can occur.

Management Strategies:

• Increase fiber gradually (fruits, vegetables, whole grains)
• Stay well-hydrated (8-10 glasses of water daily)
• Add a probiotic supplement
• Exercise regularly to promote digestion
• Avoid foods that trigger your symptoms

4. Fatigue

Some patients feel tired, especially if eating significantly less.

Management Strategies:

• Ensure adequate protein intake (25-30g per meal)
• Stay hydrated
• Maintain regular sleep schedule
• Take a multivitamin to prevent deficiencies
• Gentle exercise can actually boost energy

5. Injection Site Reactions

Mild redness, swelling, or bruising at injection site.

Management Strategies:

• Rotate injection sites (abdomen, thigh, upper arm)
• Let medication reach room temperature before injecting
• Use proper injection technique
• Apply ice before injection to numb area
• Avoid injecting in same spot repeatedly

When Side Effects Improve

Most side effects follow this timeline:

• Week 1-2: Peak side effects, especially nausea
• Week 3-4: Side effects begin to decrease
• Week 5-8: Most side effects resolve
• After dose increase: Mild temporary recurrence possible

Dosing Strategy to Minimize Side Effects

YourSkinnyRx uses a gradual dose escalation approach:

• Start with lowest effective dose
• Increase slowly every 4 weeks
• Stay at current dose if side effects are troublesome
• Individualize based on tolerance and weight loss progress

Red Flags: When to Contact Your Provider

Contact YourSkinnyRx immediately if you experience:

• Severe abdominal pain
• Persistent vomiting (can't keep food/water down)
• Signs of pancreatitis (severe stomach pain radiating to back)
• Severe allergic reaction (difficulty breathing, swelling)
• Changes in vision
• Rapid heartbeat or chest pain

The Bottom Line

While side effects can be uncomfortable, they're usually temporary and manageable. Most patients find that the weight loss benefits far outweigh the temporary discomfort. Your YourSkinnyRx medical team is available 24/7 to help you navigate any challenges.

Remember: Everyone's experience is different. What causes severe nausea in one person might cause no issues in another. Work closely with your provider to find the right approach for you.

Questions about side effects? Our medical team is here to help. Reach out anytime at support@yourskinnyrx.com or call 1-888-979-9580.